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What is the mechanism of action of hydroxyurea? Mechanism of action Hydroxycarbamide decreases the production of deoxyribonucleotides via inhibition of the enzyme ribonucleotide reductase by scavenging tyrosyl free radicals as they are involved in the reduction of nucleoside diphosphates (NDPs).
Does hydroxycarbamide make you tired? Low cell counts Hydroxycarbamide can cause side effects because the drug reduces blood cell counts across the board. Increased fatigue Hydroxycarbamide can increase fatigue. However, it is sometimes difficult to know whether the drug itself is causing the fatigue as feeling tired is also a symptom of MPNs.
Does Medicare cover brand name drugs? Depending on your condition, a generic drug may not be available, or it may be medically necessary for you to take the brand - name drug. Some Medicare Prescription Drug Plans use step therapy, which requires you to first try a lower-cost medication before the plan will cover a more expensive drug.
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